THE HUMAN CYTOMEGALOVIRUS MAJOR IMMEDIATE-EARLY PROTEINS AS ANTAGONISTS OF INTRINSIC AND INNATE ANTIVIRAL HOST RESPONSES

The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses

The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a a&d ej-123 decisive role in acute infection and its activity is an important indicator of viral reactivation from latency.Although a variety of gene products are expressed from this region, the 72-kDa IE1 and the 86-kDa IE2 nuclear phosphoproteins are the most

read more

Cluster Analysis of the Organic Peaks in Bulk Mass Spectra Obtained During the 2002 New England Air Quality Study with an Aerodyne Aerosol Mass Spectrometer

We applied hierarchical cluster analysis to an Aerodyne aerosol mass spectrometer (AMS) bulk mass spectral dataset collected aboard 2006 nissan altima radio the NOAA research vessel R.H.Brown during the 2002 New England Air Quality Study off the east coast of the United States.Emphasizing the organic peaks, the cluster analysis yielded a series of

read more

Effect of Preexisting Immunity to Tetanus Toxoid on the Efficacy of Tetanus Toxoid-Conjugated Heroin Vaccine in Mice

Opioid use disorder (OUD) is a serious health problem that has dramatically increased over the last decade.Although current therapies for the management of OUD can be effective, they have limitations.The complementary strategy to combat the opioid crisis is the development of a conjugate vaccine to generate high affinity antibodies in order to neut

read more

Prediction of endoplasmic reticulum resident proteins using fragmented amino acid composition and support vector machine

Background The endoplasmic reticulum plays an important role in many cellular processes, which includes protein synthesis, folding and post-translational processing of newly synthesized proteins.It is also the site for quality control of misfolded proteins and entry point of extracellular proteins to the secretory pathway.Hence at any given point o

read more